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What is the Islamic ruling on blood donation? Specifically, I am referring to donating blood in America and knowing it will probably go to non-Muslims.
It is permissible for a Muslim to donate blood to a non-Muslim, except when that non-Muslim is known to be in a position of fighting the Muslims.
Praise be to Allah.
It is permissible for a Muslim to donate blood to a non-Muslim, except when that non-Muslim is known to be in a position of fighting the Muslims (either by belonging to a state which is in a state of war with Muslims or by supporting aggression towards them).
In such a case, it is not permissible to donate blood, because this will help them to fight Muslims.
If the Muslim has no way of knowing to whom his blood will go, he should act according to what he thinks is most likely to happen. If he thinks that it is most likely to go to a non-Muslim who is not fighting the Muslims, it is permitted to donate, otherwise it is not.
For more details, please see the following answers: 3854, 212, 3238, 2756,
And Allah knows best.